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B014238 - GENERAL PATHOLOGY II
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2016-17
Coorte 2014 - 6-years Single Cycle Degree in Medicine and Surgery
Course year
Third year - Second Semester
Belonging Department
Experimantal and Clinical Medicine
Modulo di sola Frequenza of
Scientific Area
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Credits
4
Teaching Hours
48
Teaching Term
01/03/2017 ⇒ 30/04/2018
Attendance required
Yes
Type of Evaluation
Giudizio Finale
Course Content
show
Course program
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Lectureship
- Part A ANNUNZIATO FRANCESCO
- Part A BARLETTA EMANUELA
- Part A DEL ROSSO MARIO
- Part A DELLO SBARBA PERSIO
- Part B ARCANGELI ANNAROSA
- Part B CALORINI LIDO
- Part B DEL ROSSO MARIO
- Part B MONTI DANIELA
Teaching Language - Part A
Italian
Teaching Language - Part B
Italian
Course Content - Part A
BLOOD DISORDERS
PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
PATHOPHYSIOLOGY OF ACID BASE BALANCE
CALCIUM AND PHOSPHORUS BALANCE DISORDERS
PATHOPHYSIOLOGY OF LIPID DISORDERS
METABOLIC DISEASES
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
Histopathology of high-definition digital images of tissue sections - i.e. virtual
microscopy - illustrating the morphological basis of thrombosis, atherosclerosis, benign and malignant tumours
PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
PATHOPHYSIOLOGY OF ACID BASE BALANCE
CALCIUM AND PHOSPHORUS BALANCE DISORDERS
PATHOPHYSIOLOGY OF LIPID DISORDERS
METABOLIC DISEASES
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
Histopathology of high-definition digital images of tissue sections - i.e. virtual
microscopy - illustrating the morphological basis of thrombosis, atherosclerosis, benign and malignant tumours
Course Content - Part B
BLOOD DISORDERS
PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
PATHOPHYSIOLOGY OF ACID BASE BALANCE
CALCIUM AND PHOSPHORUS BALANCE DISORDERS
PATHOPHYSIOLOGY OF LIPID DISORDERS
METABOLIC DISEASES
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
Histopathology of high-definition digital images of tissue sections - i.e. virtual
microscopy - illustrating the morphological basis of thrombosis, atherosclerosis, benign and malignant tumours
PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
PATHOPHYSIOLOGY OF ACID BASE BALANCE
CALCIUM AND PHOSPHORUS BALANCE DISORDERS
PATHOPHYSIOLOGY OF LIPID DISORDERS
METABOLIC DISEASES
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
Histopathology of high-definition digital images of tissue sections - i.e. virtual
microscopy - illustrating the morphological basis of thrombosis, atherosclerosis, benign and malignant tumours
Suggested readings - Part A (Search our library's catalogue)
Vinay Kumar & Abul K. Abbas & Jon C. Aster
“Robbins & Cotran Pathologic Basis of Disease", 9th Edition - Elsevier
http://www.us.elsevierhealth.com/robbins-cotran-pathologic-basis-of-disease-9781455726134.html
Abul K. Abbas & Andrew H. Lichtman & Shiv Pillai "Cellular and Molecular Immunology", 8th Edition - Elsevier
http://www.us.elsevierhealth.com/cellular-and-molecular-immunology-9780323222754.html
Recomented textbook for deeper knowledges:
Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo "Harrison's Principles of Internal Medicine", vol. 1 and 2, 19th Edition - McGraw-Hill
HISTOPATHOLOGY ATLAS
G. O'Dowd, W. Stewart and B. Young
"Wheater's Basic Pathology: A Text, Atlas and Review of Histopathology", 5th Edition - Elsevier
http://store.elsevier.com/product.jsp?isbn=9780443067976&pagename=search
M. Chevanne, R.Caldini
"Immagini di Istopatologia"
Firenze University Press - Open Access
http://electronica.unifi.it/online/atlante/
“Robbins & Cotran Pathologic Basis of Disease", 9th Edition - Elsevier
http://www.us.elsevierhealth.com/robbins-cotran-pathologic-basis-of-disease-9781455726134.html
Abul K. Abbas & Andrew H. Lichtman & Shiv Pillai "Cellular and Molecular Immunology", 8th Edition - Elsevier
http://www.us.elsevierhealth.com/cellular-and-molecular-immunology-9780323222754.html
Recomented textbook for deeper knowledges:
Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo "Harrison's Principles of Internal Medicine", vol. 1 and 2, 19th Edition - McGraw-Hill
HISTOPATHOLOGY ATLAS
G. O'Dowd, W. Stewart and B. Young
"Wheater's Basic Pathology: A Text, Atlas and Review of Histopathology", 5th Edition - Elsevier
http://store.elsevier.com/product.jsp?isbn=9780443067976&pagename=search
M. Chevanne, R.Caldini
"Immagini di Istopatologia"
Firenze University Press - Open Access
http://electronica.unifi.it/online/atlante/
Suggested readings - Part B (Search our library's catalogue)
Vinay Kumar & Abul K. Abbas & Jon C. Aster
“Robbins & Cotran Pathologic Basis of Disease", 9th Edition - Elsevier
http://www.us.elsevierhealth.com/robbins-cotran-pathologic-basis-of-disease-9781455726134.html
Abul K. Abbas & Andrew H. Lichtman & Shiv Pillai "Cellular and Molecular Immunology", 8th Edition - Elsevier
http://www.us.elsevierhealth.com/cellular-and-molecular-immunology-9780323222754.html
Recomented textbook for deeper knowledges:
Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo "Harrison's Principles of Internal Medicine", vol. 1 and 2, 19th Edition - McGraw-Hill
HISTOPATHOLOGY ATLAS
G. O'Dowd, W. Stewart and B. Young
"Wheater's Basic Pathology: A Text, Atlas and Review of Histopathology", 5th Edition - Elsevier
http://store.elsevier.com/product.jsp?isbn=9780443067976&pagename=search
M. Chevanne, R.Caldini
"Immagini di Istopatologia"
Firenze University Press - Open Access
http://electronica.unifi.it/online/atlante/
“Robbins & Cotran Pathologic Basis of Disease", 9th Edition - Elsevier
http://www.us.elsevierhealth.com/robbins-cotran-pathologic-basis-of-disease-9781455726134.html
Abul K. Abbas & Andrew H. Lichtman & Shiv Pillai "Cellular and Molecular Immunology", 8th Edition - Elsevier
http://www.us.elsevierhealth.com/cellular-and-molecular-immunology-9780323222754.html
Recomented textbook for deeper knowledges:
Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo "Harrison's Principles of Internal Medicine", vol. 1 and 2, 19th Edition - McGraw-Hill
HISTOPATHOLOGY ATLAS
G. O'Dowd, W. Stewart and B. Young
"Wheater's Basic Pathology: A Text, Atlas and Review of Histopathology", 5th Edition - Elsevier
http://store.elsevier.com/product.jsp?isbn=9780443067976&pagename=search
M. Chevanne, R.Caldini
"Immagini di Istopatologia"
Firenze University Press - Open Access
http://electronica.unifi.it/online/atlante/
Learning Objectives - Part A
The student will acquire basic skills of pathophysiology in order to better understand systemic pathology and the clinical medicine.
Learning Objectives - Part B
The student will acquire basic skills of pathophysiology in order to better understand systemic pathology and the clinical medicine.
Prerequisites - Part A
Course Requirements are set by Course Degree
Prerequisites - Part B
Course Requirements are set by Course Degree
Teaching Methods - Part A
Lectures in classroom, e-learning, practical training in general histopathology
organized in small student groups (i.e AFP III-General Histopathology Module)
organized in small student groups (i.e AFP III-General Histopathology Module)
Teaching Methods - Part B
Lectures in classroom, e-learning, practical training in general histopathology
organized in small student groups (i.e AFP III-General Histopathology Module)
organized in small student groups (i.e AFP III-General Histopathology Module)
Further information - Part A
Coordinator: Prof. Emanuela Barletta
Office hours of Teachers of the Integrated Course: daily by appointment.
E-learning:
https://e-l.unifi.it/course/index.php?categoryid=330
Office hours of Teachers of the Integrated Course: daily by appointment.
E-learning:
https://e-l.unifi.it/course/index.php?categoryid=330
Further information - Part B
Coordinator: Prof. Emanuela Barletta
Office hours of Teachers of the Integrated Course: daily by appointment.
E-learning:
https://e-l.unifi.it/course/index.php?categoryid=330
Office hours of Teachers of the Integrated Course: daily by appointment.
E-learning:
https://e-l.unifi.it/course/index.php?categoryid=330
Type of Assessment - Part A
Assessment methods
The final examination of the whole integrated course aims to assess the achievement of the objectives of the integrated course (General Pathology I & II). It consists of specific questions - oral questions during exam session and written tests during ongoing e-learning - about the different subjects included in the whole program of the integrated course.
Moreover the final evaluation of the integrated course also takes into account the assessment achieved during the Training Activities for Professionalization (third year) (AFP III) - "General Histopathology" Module.
The board of examiners will be composed for each exam session by teachers of either channels of the integrated course and by teachers of AFPIII-"General Histopathology" Module.
During the academic year students can access to 10 official exam sessions: 4 in the summer session, June-July; 2 in the autumn session of September; and 4 and in the winter session, January-February.
Attendance
Admission to the final examination is subject to the attendance of the Course.
Attendance is assessed as follows:
1) regular attendance at lessons in classroom - is mandatory;
2) attendance at the AFP III- "Hystopathology" is mandatory in order to get the attendance at the Course of General Pathology;
3) activities carried out in the e-learning platform are mandatory to get the attendance at the Course of General Pathology.
The final examination of the whole integrated course aims to assess the achievement of the objectives of the integrated course (General Pathology I & II). It consists of specific questions - oral questions during exam session and written tests during ongoing e-learning - about the different subjects included in the whole program of the integrated course.
Moreover the final evaluation of the integrated course also takes into account the assessment achieved during the Training Activities for Professionalization (third year) (AFP III) - "General Histopathology" Module.
The board of examiners will be composed for each exam session by teachers of either channels of the integrated course and by teachers of AFPIII-"General Histopathology" Module.
During the academic year students can access to 10 official exam sessions: 4 in the summer session, June-July; 2 in the autumn session of September; and 4 and in the winter session, January-February.
Attendance
Admission to the final examination is subject to the attendance of the Course.
Attendance is assessed as follows:
1) regular attendance at lessons in classroom - is mandatory;
2) attendance at the AFP III- "Hystopathology" is mandatory in order to get the attendance at the Course of General Pathology;
3) activities carried out in the e-learning platform are mandatory to get the attendance at the Course of General Pathology.
Type of Assessment - Part B
Assessment methods
The final examination of the whole integrated course aims to assess the achievement of the objectives of the integrated course (General Pathology I & II). It consists of specific questions - oral questions during exam session and written tests during ongoing e-learning - about the different subjects included in the whole program of the integrated course.
Moreover the final evaluation of the integrated course also takes into account the assessment achieved during the Training Activities for Professionalization (third year) (AFP III) - "General Histopathology" Module.
The board of examiners will be composed for each exam session by teachers of either channels of the integrated course and by teachers of AFPIII-"General Histopathology" Module.
During the academic year students can access to 10 official exam sessions: 4 in the summer session, June-July; 2 in the autumn session of September; and 4 and in the winter session, January-February.
Attendance
Admission to the final examination is subject to the attendance of the Course.
Attendance is assessed as follows:
1) regular attendance at lessons in classroom - is mandatory;
2) attendance at the AFP III- "Hystopathology" is mandatory in order to get the attendance at the Course of General Pathology;
3) activities carried out in the e-learning platform are mandatory to get the attendance at the Course of General Pathology.
The final examination of the whole integrated course aims to assess the achievement of the objectives of the integrated course (General Pathology I & II). It consists of specific questions - oral questions during exam session and written tests during ongoing e-learning - about the different subjects included in the whole program of the integrated course.
Moreover the final evaluation of the integrated course also takes into account the assessment achieved during the Training Activities for Professionalization (third year) (AFP III) - "General Histopathology" Module.
The board of examiners will be composed for each exam session by teachers of either channels of the integrated course and by teachers of AFPIII-"General Histopathology" Module.
During the academic year students can access to 10 official exam sessions: 4 in the summer session, June-July; 2 in the autumn session of September; and 4 and in the winter session, January-February.
Attendance
Admission to the final examination is subject to the attendance of the Course.
Attendance is assessed as follows:
1) regular attendance at lessons in classroom - is mandatory;
2) attendance at the AFP III- "Hystopathology" is mandatory in order to get the attendance at the Course of General Pathology;
3) activities carried out in the e-learning platform are mandatory to get the attendance at the Course of General Pathology.
Course program - Part A
1. BLOOD DISORDERS
Overview of stem cell biology and cellular biology of haematopoiesis.
Erythroid maturation and differentiation
Humoral regulation in normal erythropoiesis.
Pathobiology of human erythrocyte and haemoglobin.
Anaemia: definition, classification of anemia- morphological and etiological.
Polycythemia: primary and secondary polycythemia.
2. PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
Key regulators in fluid and electrolyte balance.
Fluid volume deficit and excess.
Sodium and Potassium imbalance: hypo- and hypernatriemia, hypo- and hyperkalemia.
3. PATHOPHYSIOLOGY OF ACID BASE BALANCE
Overview of buffer systems and acid-base balance.
Pathogenesis of metabolic and respiratory alkalosis and acidosis.
Pathogenesis of metabolic and respiratory alkalemia and acidemia.
Mixed acid base disorders.
4. CALCIUM AND PHOSPHORUS BALANCE DISORDERS
Overview of calcium, phosporous and magnesium balance.
Regulation of calcium metabolism: Parathyroid hormone and vitamin D.
Pathogenesis of hyper- and hyporcalcemia.
5. PATHOPHYSIOLOGY OF LIPID DISORDERS
Hyperlipoproteinemia: definition, classification and pathogenesis.
Hyperlipoproteinemia and atherogenesis.
6. METABOLIC DISEASES
Pathogenesis of hyperuricemia and gut.
Diabetes mellitus: definition, classificatioin, epidemiology, pathogenesis, morphology; diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome; long-term complications of diabetes.
Etiology and pathophysiology of pathologic hyperbilirubinemia: jaundice.
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
By the end of this activity, the students will be able to recognize and describe microscopic features of:
thrombosis and atherosclerosis;
differences between a benign and malignant tumour, including cytological atypia/dysplasia.
Overview of stem cell biology and cellular biology of haematopoiesis.
Erythroid maturation and differentiation
Humoral regulation in normal erythropoiesis.
Pathobiology of human erythrocyte and haemoglobin.
Anaemia: definition, classification of anemia- morphological and etiological.
Polycythemia: primary and secondary polycythemia.
2. PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
Key regulators in fluid and electrolyte balance.
Fluid volume deficit and excess.
Sodium and Potassium imbalance: hypo- and hypernatriemia, hypo- and hyperkalemia.
3. PATHOPHYSIOLOGY OF ACID BASE BALANCE
Overview of buffer systems and acid-base balance.
Pathogenesis of metabolic and respiratory alkalosis and acidosis.
Pathogenesis of metabolic and respiratory alkalemia and acidemia.
Mixed acid base disorders.
4. CALCIUM AND PHOSPHORUS BALANCE DISORDERS
Overview of calcium, phosporous and magnesium balance.
Regulation of calcium metabolism: Parathyroid hormone and vitamin D.
Pathogenesis of hyper- and hyporcalcemia.
5. PATHOPHYSIOLOGY OF LIPID DISORDERS
Hyperlipoproteinemia: definition, classification and pathogenesis.
Hyperlipoproteinemia and atherogenesis.
6. METABOLIC DISEASES
Pathogenesis of hyperuricemia and gut.
Diabetes mellitus: definition, classificatioin, epidemiology, pathogenesis, morphology; diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome; long-term complications of diabetes.
Etiology and pathophysiology of pathologic hyperbilirubinemia: jaundice.
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
By the end of this activity, the students will be able to recognize and describe microscopic features of:
thrombosis and atherosclerosis;
differences between a benign and malignant tumour, including cytological atypia/dysplasia.
Course program - Part B
1. BLOOD DISORDERS
Overview of stem cell biology and cellular biology of haematopoiesis.
Erythroid maturation and differentiation
Humoral regulation in normal erythropoiesis.
Pathobiology of human erythrocyte and haemoglobin.
Anaemia: definition, classification of anemia- morphological and etiological.
Polycythemia: primary and secondary polycythemia.
2. PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
Key regulators in fluid and electrolyte balance.
Fluid volume deficit and excess.
Sodium and Potassium imbalance: hypo- and hypernatriemia, hypo- and hyperkalemia.
3. PATHOPHYSIOLOGY OF ACID BASE BALANCE
Overview of buffer systems and acid-base balance.
Pathogenesis of metabolic and respiratory alkalosis and acidosis.
Pathogenesis of metabolic and respiratory alkalemia and acidemia.
Mixed acid base disorders.
4. CALCIUM AND PHOSPHORUS BALANCE DISORDERS
Overview of calcium, phosporous and magnesium balance.
Regulation of calcium metabolism: Parathyroid hormone and vitamin D.
Pathogenesis of hyper- and hyporcalcemia.
5. PATHOPHYSIOLOGY OF LIPID DISORDERS
Hyperlipoproteinemia: definition, classification and pathogenesis.
Hyperlipoproteinemia and atherogenesis.
6. METABOLIC DISEASES
Pathogenesis of hyperuricemia and gut.
Diabetes mellitus: definition, classificatioin, epidemiology, pathogenesis, morphology; diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome; long-term complications of diabetes.
Etiology and pathophysiology of pathologic hyperbilirubinemia: jaundice.
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
By the end of this activity, the students will be able to recognize and describe microscopic features of:
thrombosis and atherosclerosis;
differences between a benign and malignant tumour, including cytological atypia/dysplasia.
Overview of stem cell biology and cellular biology of haematopoiesis.
Erythroid maturation and differentiation
Humoral regulation in normal erythropoiesis.
Pathobiology of human erythrocyte and haemoglobin.
Anaemia: definition, classification of anemia- morphological and etiological.
Polycythemia: primary and secondary polycythemia.
2. PATHOPHYSIOLOGY OF FLUID AND ELECTROLYTE BALANCE
Key regulators in fluid and electrolyte balance.
Fluid volume deficit and excess.
Sodium and Potassium imbalance: hypo- and hypernatriemia, hypo- and hyperkalemia.
3. PATHOPHYSIOLOGY OF ACID BASE BALANCE
Overview of buffer systems and acid-base balance.
Pathogenesis of metabolic and respiratory alkalosis and acidosis.
Pathogenesis of metabolic and respiratory alkalemia and acidemia.
Mixed acid base disorders.
4. CALCIUM AND PHOSPHORUS BALANCE DISORDERS
Overview of calcium, phosporous and magnesium balance.
Regulation of calcium metabolism: Parathyroid hormone and vitamin D.
Pathogenesis of hyper- and hyporcalcemia.
5. PATHOPHYSIOLOGY OF LIPID DISORDERS
Hyperlipoproteinemia: definition, classification and pathogenesis.
Hyperlipoproteinemia and atherogenesis.
6. METABOLIC DISEASES
Pathogenesis of hyperuricemia and gut.
Diabetes mellitus: definition, classificatioin, epidemiology, pathogenesis, morphology; diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome; long-term complications of diabetes.
Etiology and pathophysiology of pathologic hyperbilirubinemia: jaundice.
TRAINING ACTIVITIES FOR PROFESSIONALIZATION (THIRD YEAR)
By the end of this activity, the students will be able to recognize and describe microscopic features of:
thrombosis and atherosclerosis;
differences between a benign and malignant tumour, including cytological atypia/dysplasia.